Endocrine Abstracts

AROM+ mice express universally the human P450 aromatase enzyme, leading to increased serum and intratesticular E2/T ratio. AROM+ mice are infertile and present with testicular inflammation characterized by a high amount of macrophages, mast cells and fibrosis. Interestingly, testis macrophage and mast cell infiltration together with fibrosis has also been connected to infertility in men. The aim of the study was to find out whether there are similar changes at the molecular le...